Response Gene to Complement 32 in Vascular Diseases
نویسندگان
چکیده
منابع مشابه
Response gene to complement 32 (RGC-32) in endothelial cells is induced by glucose and helpful to maintain glucose homeostasis.
Endothelium dysfunction has been understood primarily in terms of abnormal vasomotor function, which plays an important role in the pathogenesis of diabetes and chronic diabetic complications. However, it has not been fully studied that the endothelium may regulate metabolism itself. The response gene to complement 32 (RGC-32) has be considered as an angiogenic inhibitor in the context of endot...
متن کاملResponse gene to complement 32 promotes vascular lesion formation through stimulation of smooth muscle cell proliferation and migration.
OBJECTIVE The objectives of this study were to determine the role of response gene to complement 32 (RGC-32) in vascular lesion formation after experimental angioplasty and to explore the underlying mechanisms. METHODS AND RESULTS Using a rat carotid artery balloon-injury model, we documented for the first time that neointima formation was closely associated with a significantly increased exp...
متن کاملResponse gene to complement 32 deficiency causes impaired placental angiogenesis in mice.
AIMS The objectives of this study are to determine the role of response gene to complement 32 (RGC-32) in the placental angiogenesis during pregnancy and explore the underlying mechanisms. METHODS AND RESULTS RGC-32-deficient (RGC32(-/-)) mice were generated from C57BL/6 embryonic stem cells with deletion of exon 2 and 3 of the RGC-32 gene. Most of the RGC32(-/-) mice can survive. However, th...
متن کاملPromoter Methylation and mRNA Expression of Response Gene to Complement 32 in Breast Carcinoma
Background. Response gene to complement 32 (RGC32), induced by activation of complements, has been characterized as a cell cycle regulator; however, its role in carcinogenesis is still controversial. In the present study we compared RGC32 promoter methylation patterns and mRNA expression in breast cancerous tissues and adjacent normal tissues. Materials and Methods. Sixty-three breast cancer ti...
متن کاملResponse gene to complement 32 is essential for fibroblast activation in renal fibrosis.
Response gene to complement 32 (RGC-32) is a downstream target of transforming growth factor-β (TGF-β). TGF-β is known to play a pathogenic role in renal fibrosis. In this study, we investigated RGC-32 function in renal fibrosis following unilateral ureteral obstruction (UUO) in mice, a model of progressive tubulointerstitial fibrosis. RGC-32 is normally expressed only in blood vessels of mouse...
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ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2018
ISSN: 2297-055X
DOI: 10.3389/fcvm.2018.00128